My Life is Murder doesn't appear to have been picked up by Channel 10 for Season 2 (yet). No news about it in the Channel 10 upfronts where they showcase all the new shows and returning shows. Doesn’t mean it’s cancelled, just deferred.
There is a possibility of the show coming back in 2022. Lots of factors could have gone into why Season 2 is not being filmed and one of the major (if not the major one) is that Melbourne is in the middle of a COVID crisis with the state in semi-lockdown.